Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein
Alpha-1-antitrypsin (AAT) deficiency results from misfolding-prone AAT variants. Here the authors show that AAT forms co-translational folding intermediates on the ribosome that persist upon release and determine its folding fate. They show too that the ribosome can also modulate misfolding-prone AA...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26531-1 |
| _version_ | 1818936020086816768 |
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| author | Elena Plessa Lien P. Chu Sammy H. S. Chan Oliver L. Thomas Anaïs M. E. Cassaignau Christopher A. Waudby John Christodoulou Lisa D. Cabrita |
| author_facet | Elena Plessa Lien P. Chu Sammy H. S. Chan Oliver L. Thomas Anaïs M. E. Cassaignau Christopher A. Waudby John Christodoulou Lisa D. Cabrita |
| author_sort | Elena Plessa |
| collection | DOAJ |
| description | Alpha-1-antitrypsin (AAT) deficiency results from misfolding-prone AAT variants. Here the authors show that AAT forms co-translational folding intermediates on the ribosome that persist upon release and determine its folding fate. They show too that the ribosome can also modulate misfolding-prone AAT intermediates during their synthesis. |
| first_indexed | 2024-12-20T05:29:25Z |
| format | Article |
| id | doaj.art-30b1313e15054f30a9de5b5032f07b04 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T05:29:25Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-30b1313e15054f30a9de5b5032f07b042022-12-21T19:51:47ZengNature PortfolioNature Communications2041-17232021-11-0112111310.1038/s41467-021-26531-1Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing proteinElena Plessa0Lien P. Chu1Sammy H. S. Chan2Oliver L. Thomas3Anaïs M. E. Cassaignau4Christopher A. Waudby5John Christodoulou6Lisa D. Cabrita7Institute of Structural and Molecular Biology, University College LondonInstitute of Structural and Molecular Biology, University College LondonInstitute of Structural and Molecular Biology, University College LondonInstitute of Structural and Molecular Biology, University College LondonInstitute of Structural and Molecular Biology, University College LondonInstitute of Structural and Molecular Biology, University College LondonInstitute of Structural and Molecular Biology, University College LondonInstitute of Structural and Molecular Biology, University College LondonAlpha-1-antitrypsin (AAT) deficiency results from misfolding-prone AAT variants. Here the authors show that AAT forms co-translational folding intermediates on the ribosome that persist upon release and determine its folding fate. They show too that the ribosome can also modulate misfolding-prone AAT intermediates during their synthesis.https://doi.org/10.1038/s41467-021-26531-1 |
| spellingShingle | Elena Plessa Lien P. Chu Sammy H. S. Chan Oliver L. Thomas Anaïs M. E. Cassaignau Christopher A. Waudby John Christodoulou Lisa D. Cabrita Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein Nature Communications |
| title | Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein |
| title_full | Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein |
| title_fullStr | Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein |
| title_full_unstemmed | Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein |
| title_short | Nascent chains can form co-translational folding intermediates that promote post-translational folding outcomes in a disease-causing protein |
| title_sort | nascent chains can form co translational folding intermediates that promote post translational folding outcomes in a disease causing protein |
| url | https://doi.org/10.1038/s41467-021-26531-1 |
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