Centaur antibodies: Engineered chimeric equine-human recombinant antibodies

Centaur antibodies: Engineered chimeric equine-human recombinant antibodies

Hyper-immune antisera from large mammals, in particular horses, are routinely used for life-saving anti-intoxication intervention. While highly efficient, the use of these immunotherapeutics is complicated by possible recipient reactogenicity and limited availability. Accordingly, there is an urgent...

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Bibliographic Details
Main Authors: Ronit Rosenfeld, Ron Alcalay, Anat Zvi, Alon Ben-David, Tal Noy-Porat, Theodor Chitlaru, Eyal Epstein, Ofir Israeli, Shirley Lazar, Noa Caspi, Ada Barnea, Eyal Dor, Inbar Chomsky, Shani Pitel, Efi Makdasi, Ran Zichel, Ohad Mazor
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
antibody engineering
phage display
equine V-genes
anti-toxins
anti-venoms
botulinum
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.942317/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.942317/full

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