Highly Variable Expression of Merozoite Surface Protein MSPDBL2 in Diverse Plasmodium falciparum Clinical Isolates and Transcriptome Scans for Correlating Genes

Highly Variable Expression of Merozoite Surface Protein MSPDBL2 in Diverse Plasmodium falciparum Clinical Isolates and Transcriptome Scans for Correlating Genes

ABSTRACT The merozoite surface protein MSPDBL2 of Plasmodium falciparum is under strong balancing selection and is a target of naturally acquired antibodies. Remarkably, MSPDBL2 is expressed in only a minority of mature schizonts of any cultured parasite line, and mspdbl2 gene transcription increase...

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Bibliographic Details
Main Authors: Suzanne E. Hocking, Lindsay B. Stewart, Aline Freville, Adam J. Reid, Sarah J. Tarr, Kevin K. A. Tetteh, Christian Flueck, Ambroise D. Ahouidi, Alfred Amambua-Ngwa, Mahamadou Diakite, Gordon A. Awandare, David J. Conway
Format: Article
Language:English
Published: American Society for Microbiology 2022-08-01
Series:mBio
Subjects:
antigenic variation
blood culture
malaria
sexual development
transcription
Online Access:https://journals.asm.org/doi/10.1128/mbio.01948-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01948-22

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