Hydroxide-Mediated S<sub>N</sub>Ar Rearrangement for Synthesis of Novel Depside Derivatives Containing Diaryl Ether Skeleton as Antitumor Agents
A simple and efficient hydroxide-mediated S<sub>N</sub>Ar rearrangement was reported to synthesize new depside derivatives containing the diaryl ether skeleton from the natural product barbatic acid. The prepared compounds were determined using <sup>1</sup>H NMR, <sup>1...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/11/4303 |
| Summary: | A simple and efficient hydroxide-mediated S<sub>N</sub>Ar rearrangement was reported to synthesize new depside derivatives containing the diaryl ether skeleton from the natural product barbatic acid. The prepared compounds were determined using <sup>1</sup>H NMR, <sup>13</sup>C NMR, HRMS, and X-ray crystallographic analysis and were also screened in vitro for cytotoxicity against three cancer cell lines and one normal cell line. The evaluation results showed that compound <b>3b</b> possessed the best antiproliferative activity against liver cancer HepG2 cell line and low toxicity, which made it worth further study. |
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| ISSN: | 1420-3049 |