A Comparative Analysis of Punicalagin Interaction with PDIA1 and PDIA3 by Biochemical and Computational Approaches

A Comparative Analysis of Punicalagin Interaction with PDIA1 and PDIA3 by Biochemical and Computational Approaches

In a previous work, it was shown that punicalagin, an active ingredient of pomegranate, is able to bind to PDIA3 and inhibit its disulfide reductase activity. Here we provide evidence that punicalagin can also bind to PDIA1, the main expressed form of protein disulfide isomerase (PDI). In this compa...

Full description

Bibliographic Details
Main Authors: Giuliano Paglia, Lorenzo Antonini, Laura Cervoni, Rino Ragno, Manuela Sabatino, Marco Minacori, Elisabetta Rubini, Fabio Altieri
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomedicines
Subjects:
protein disulfide isomerase
PDIA3/ERp57
inhibitor
punicalagin
molecular docking
molecular dynamics
Online Access:https://www.mdpi.com/2227-9059/9/11/1533

Internet

https://www.mdpi.com/2227-9059/9/11/1533

Similar Items