Modulation of the Microglial Nogo-A/NgR Signaling Pathway as a Therapeutic Target for Multiple Sclerosis

Modulation of the Microglial Nogo-A/NgR Signaling Pathway as a Therapeutic Target for Multiple Sclerosis

Current therapeutics targeting chronic phases of multiple sclerosis (MS) are considerably limited in reversing the neural damage resulting from repeated inflammation and demyelination insults in the multi-focal lesions. This inflammation is propagated by the activation of microglia, the endogenous i...

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Bibliographic Details
Main Authors: Danica Nheu, Olivia Ellen, Sining Ye, Ezgi Ozturk, Maurice Pagnin, Stephen Kertadjaja, Paschalis Theotokis, Nikolaos Grigoriadis, Catriona McLean, Steven Petratos
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Cells
Subjects:
multiple sclerosis
microglia
microglial polarization
classically activated microglia
alternatively activated microglia
Nogo-A
Online Access:https://www.mdpi.com/2073-4409/11/23/3768

Internet

https://www.mdpi.com/2073-4409/11/23/3768

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