Potential crosstalk between SPP1 + TAMs and CD8 + exhausted T cells promotes an immunosuppressive environment in gastric metastatic cancer

Potential crosstalk between SPP1 + TAMs and CD8 + exhausted T cells promotes an immunosuppressive environment in gastric metastatic cancer

Abstract Background Immunotherapy brings new hope to patients with advanced gastric cancer. However, liver metastases can reduce the efficacy of immunotherapy in patients. Tumor-associated macrophages (TAMs) may be the cause of this reduction in efficacy. SPP1 + TAMs are considered to have immunosup...

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Bibliographic Details
Main Authors: Yan Du, Yilin Lin, Lin Gan, Shuo Wang, Shuang Chen, Chen Li, Sen Hou, Bozhi Hu, Bo Wang, Yingjiang Ye, Zhanlong Shen
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Translational Medicine
Subjects:
Gastric metastatic cancer
SPP1 + TAMs
CD8 + T exhausted cells
Immunosuppressive
Single-cell analysis
Online Access:https://doi.org/10.1186/s12967-023-04688-1

Internet

https://doi.org/10.1186/s12967-023-04688-1

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