Antimalarial activity of a novel series of artemisinin-derived 1, 2, 3-triazole dimers

Antimalarial activity of a novel series of artemisinin-derived 1, 2, 3-triazole dimers

Objective: To obtain suitable artimisinin-based drug candidates with high antimalarial activity. Methods: Three different reaction schemes were used to synthesize a total of 15 artemisinin-based compounds. The first synthetic scheme involved the synthesis of diazido aliphatic and aromatic compounds...

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Bibliographic Details
Main Authors: Kabita Gogoi, Gokul Baishya, Biswajit Saikia, Nabin Chandra Barua, Chandrajit Dohutia, Akalesh Kumar Verma, Anil Prakash
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Asian Pacific Journal of Tropical Medicine
Subjects:
antimalarial activity
artemisinin derivatives
huisgen reaction
triazole dimers
plasmodium berghei
plasmodium falciparum
molecular docking
Online Access:http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=5;spage=195;epage=203;aulast=Gogoi

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http://www.apjtm.org/article.asp?issn=1995-7645;year=2019;volume=12;issue=5;spage=195;epage=203;aulast=Gogoi

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