Antiproliferative Activity of Krukovine by Regulating Transmembrane Protein 139 (TMEM139) in Oxaliplatin-Resistant Pancreatic Cancer Cells

Antiproliferative Activity of Krukovine by Regulating Transmembrane Protein 139 (TMEM139) in Oxaliplatin-Resistant Pancreatic Cancer Cells

Krukovine (KV) is an alkaloid isolated from the bark of <i>Abuta grandifolia</i> (Mart.) Sandw. (Menispermaceae) with anticancer potential in some cancers with <i>KRAS</i> mutations. In this study, we explored the anticancer efficacy and mechanism of KV in oxaliplatin-resista...

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Bibliographic Details
Main Authors: Jee-Hyung Lee, Sang-Hyub Lee, Sang-Kook Lee, Jin-Ho Choi, Seohyun Lim, Min-Song Kim, Kyung-Min Lee, Min-Woo Lee, Ja-Lok Ku, Dae-Hyun Kim, In-Rae Cho, Woo-Hyun Paik, Ji-Kon Ryu, Yong-Tae Kim
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
pancreatic cancer
krukovine
<i>KRAS</i>
transmembrane protein 139 (TMEM139)
metastasis
patient-derived pancreatic cancer organoid (PDPCO)
Online Access:https://www.mdpi.com/2072-6694/15/9/2642

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https://www.mdpi.com/2072-6694/15/9/2642

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