The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes

The Steroidal Alkaloid Tomatidine and Tomatidine-Rich Tomato Leaf Extract Suppress the Human Gastric Cancer-Derived 85As2 Cells In Vitro and In Vivo via Modulation of Interferon-Stimulated Genes

The steroidal alkaloid tomatidine is an aglycone of α-tomatine, which is abundant in tomato leaves and has several biological activities. Tomatidine has been reported to inhibit the growth of cultured cancer cells in vitro, but its anti-cancer activity in vivo and inhibitory effect against gastric c...

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Bibliographic Details
Main Authors: Junya Fujimaki, Neo Sayama, Shigenobu Shiotani, Takanori Suzuki, Miki Nonaka, Yasuhito Uezono, Mamoru Oyabu, Yasutomi Kamei, Haruo Nukaya, Keiji Wakabayashi, Akihito Morita, Tomoki Sato, Shinji Miura
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Nutrients
Subjects:
tomatidine
tomato leaves
gastric cancer
IFI27
type I interferon signaling pathway
type I interferon-stimulated genes
Online Access:https://www.mdpi.com/2072-6643/14/5/1023

Internet

https://www.mdpi.com/2072-6643/14/5/1023

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