Notch2 Increases the Resistance to Venetoclax-Induced Apoptosis in Chronic Lymphocytic Leukemia B Cells by Inducing Mcl-1

Notch2 Increases the Resistance to Venetoclax-Induced Apoptosis in Chronic Lymphocytic Leukemia B Cells by Inducing Mcl-1

Chronic lymphocytic leukemia (CLL) has experienced a clinical revolution—thanks to the discovery of crucial pathogenic mechanisms. CLL is still an incurable disease due to intrinsic or acquired resistance of the leukemic clone. Venetoclax is a Bcl-2 inhibitor with a marked activity in CLL, but emerg...

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Bibliographic Details
Main Authors: Stefania Fiorcari, Rossana Maffei, Claudio Giacinto Atene, Nicolò Mesini, Monica Maccaferri, Giovanna Leonardi, Silvia Martinelli, Ambra Paolini, Vincenzo Nasillo, Giulia Debbia, Leonardo Potenza, Mario Luppi, Roberto Marasca
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
chronic lymphocytic leukemia (CLL)
drug resistance
translational research
Notch
venetoclax (ABT-199)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.777587/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.777587/full

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