Impact of NF-κB pathway on the intervertebral disc inflammation and degeneration induced by over‐mechanical stretching stress

Impact of NF-κB pathway on the intervertebral disc inflammation and degeneration induced by over‐mechanical stretching stress

Abstract Background Intervertebral disk degeneration (IVDD) contributes to low back pain. Increased cell apoptosis and inflammation, decreased extracellular matrix are associated with IVDD. Nuclear factor-kappa B (NF-κB) signaling pathway and inflammatory cytokines are implicated in the pathophysiol...

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Bibliographic Details
Main Authors: Hui Xu, Guobao Qi, Kunpeng Li, Keshi Yang, Dawei Luo, Zhongxu Cai
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Inflammation
Subjects:
NF-κB
Intervertebral disc
Inflammation
Degeneration
Mechanical stretching stress
Online Access:https://doi.org/10.1186/s12950-021-00273-9

Internet

https://doi.org/10.1186/s12950-021-00273-9

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