Glutathione-Conjugates of Deoxynivalenol in Naturally Contaminated Grain Are Primarily Linked via the Epoxide Group

Glutathione-Conjugates of Deoxynivalenol in Naturally Contaminated Grain Are Primarily Linked via the Epoxide Group

A glutathione (GSH) adduct of the mycotoxin 4-deoxynivalenol (DON), together with a range of related conjugates, has recently been tentatively identified by LC-MS of DON-treated wheat spikelets. In this study, we prepared samples of DON conjugated at the 10- and 13-positions with GSH, Cys, CysGly, γ...

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Bibliographic Details
Main Authors: Silvio Uhlig, Ana Stanic, Ingerd S. Hofgaard, Bernhard Kluger, Rainer Schuhmacher, Christopher O. Miles
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Toxins
Subjects:
bioconjugation
HRMS
mercapturate
mycotoxin
trichothecene
thiol
LC-MS
metabolism
wheat
oats
Online Access:http://www.mdpi.com/2072-6651/8/11/329

Internet

http://www.mdpi.com/2072-6651/8/11/329

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