Polygalasaponin F protects hippocampal neurons against glutamate-induced cytotoxicity

Polygalasaponin F protects hippocampal neurons against glutamate-induced cytotoxicity

Excess extracellular glutamate leads to excitotoxicity, which induces neuronal death through the overactivation of N-methyl-D-aspartate receptors (NMDARs). Excitotoxicity is thought to be closely related to various acute and chronic neurological disorders, such as stroke and Alzheimer’s disease. Pol...

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Bibliographic Details
Main Authors: Chong Sun, Xin-Cheng Cao, Zhi-Yang Liu, Chao-Lin Ma, Bao-Ming Li
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
bdnf; ca2+ homeostasis; excitotoxicity; glutamate; hippocampal neurons; pcreb; polygalasaponin f; neuroprotection; nr2a; nr2b
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=1;spage=178;epage=184;aulast=Sun

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=1;spage=178;epage=184;aulast=Sun

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