CYLD Inhibits the Development of Skin Squamous Cell Tumors in Immunocompetent Mice

CYLD Inhibits the Development of Skin Squamous Cell Tumors in Immunocompetent Mice

Cylindromatosis (CYLD) is a deubiquitinase (DUB) enzyme that was initially characterized as a tumor suppressor of adnexal skin tumors in patients with CYLD syndrome. Later, it was also shown that the expression of functionally inactive mutated forms of CYLD promoted tumor development and progression...

Full description

Bibliographic Details
Main Authors: Josefa P. Alameda, Verónica A. García-García, Silvia López, Ana Hernando, Angustias Page, Manuel Navarro, Rodolfo Moreno-Maldonado, Jesús M. Paramio, Ángel Ramírez, Rosa A. García-Fernández, María Llanos Casanova
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
CYLD
NF-κB
epidermal differentiation
non-melanoma skin cancer
skin tumor suppressor
apoptosis
Online Access:https://www.mdpi.com/1422-0067/22/13/6736

Internet

https://www.mdpi.com/1422-0067/22/13/6736

Similar Items