The Old and New Visions of Biased Agonism Through the Prism of Adenosine Receptor Signaling and Receptor/Receptor and Receptor/Protein Interactions

The Old and New Visions of Biased Agonism Through the Prism of Adenosine Receptor Signaling and Receptor/Receptor and Receptor/Protein Interactions

Biased signaling is a concept that has arisen in the G protein-coupled receptor (GCPR) research field, and holds promise for the development of new drug development strategies. It consists of different signaling outputs depending on the agonist’s chemical structure. Here we review the most accepted...

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Bibliographic Details
Main Authors: Rafael Franco, Rafael Rivas‐Santisteban, Irene Reyes-Resina, Gemma Navarro
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
cAMP
MAPK pathway
adenylyl cyclase
GPCR
tetramer
heteromer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.628601/full

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https://www.frontiersin.org/articles/10.3389/fphar.2020.628601/full

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