Colorectal Cancer Apoptosis Induced by Dietary δ-Valerobetaine Involves PINK1/Parkin Dependent-Mitophagy and SIRT3

Colorectal Cancer Apoptosis Induced by Dietary δ-Valerobetaine Involves PINK1/Parkin Dependent-Mitophagy and SIRT3

Understanding the mechanisms of colorectal cancer progression is crucial in the setting of strategies for its prevention. δ-Valerobetaine (δVB) is an emerging dietary metabolite showing cytotoxic activity in colon cancer cells via autophagy and apoptosis. Here, we aimed to deepen current knowledge o...

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Bibliographic Details
Main Authors: Nunzia D’Onofrio, Elisa Martino, Luigi Mele, Antonino Colloca, Martina Maione, Domenico Cautela, Domenico Castaldo, Maria Luisa Balestrieri
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
colon cancer
mitophagy
mitochondrial dysfunction
PINK1/Parkin
Online Access:https://www.mdpi.com/1422-0067/22/15/8117

Internet

https://www.mdpi.com/1422-0067/22/15/8117

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