Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade

Remodeling of the tumor microenvironment via disrupting Blimp1+ effector Treg activity augments response to anti-PD-1 blockade

Abstract Background Accumulation of Foxp3+ regulatory T (Treg) cells in the tumor often represents an important mechanism for cancer immune evasion and a critical barrier to anti-tumor immunity and immunotherapy. Many tumor-infiltrating Treg cells display an activated phenotype and express the trans...

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Bibliographic Details
Main Authors: Michael L. Dixon, Lin Luo, Sadashib Ghosh, Jeffrey M. Grimes, Jonathan D. Leavenworth, Jianmei W. Leavenworth
Format: Article
Language:English
Published: BMC 2021-11-01
Series:Molecular Cancer
Subjects:
Anti-tumor immunity
Humoral antibody response
IgE
Effector regulatory T-cells
Follicular regulatory T-cells
Treg lineage stability
Online Access:https://doi.org/10.1186/s12943-021-01450-3

Internet

https://doi.org/10.1186/s12943-021-01450-3

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