The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections

The NS Segment of H1N1pdm09 Enhances H5N1 Pathogenicity in a Mouse Model of Influenza Virus Infections

In 2009, the co-circulation of H5N1 and H1N1pdm09 raised concerns that a reassortment event may lead to highly pathogenic influenza strains. H1N1pdm09 and H5N1 are able to infect the same target cells of the lower respiratory tract. To investigate the capacity of the emergence of reassortant viruses...

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Bibliographic Details
Main Authors: Olivier Ferraris, Jean-Sébastien Casalegno, Emilie Frobert, Maude Bouscambert Duchamp, Martine Valette, Frédéric Jacquot, Hervé Raoul, Bruno Lina, Michèle Ottmann
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Viruses
Subjects:
virus
influenza
influenza A
H5N1
H1N1pdm
reassortment
pathogenicity
mouse model
Online Access:http://www.mdpi.com/1999-4915/10/9/504

Internet

http://www.mdpi.com/1999-4915/10/9/504

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