Cancer associated fibroblast derived SLIT2 drives gastric cancer cell metastasis by activating NEK9

Abstract The secretory properties of cancer-associated fibroblasts (CAFs) play predominant roles in shaping a pro-metastatic tumor microenvironment. The present study demonstrated that SLIT2, an axon guidance protein, produced by CAFs and promoted gastric cancer (GC) metastasis in two gastric cancer...

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Bibliographic Details
Main Authors: Guofang Lu, Rui Du, Jiaqiang Dong, Yi Sun, Fenli Zhou, Fan Feng, Bin Feng, Ying Han, Yulong Shang
Format: Article
Language:English
Published: Nature Publishing Group 2023-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-05965-z