MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4+ T cells

MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4+ T cells

Summary: Activated-to-memory transitioning CD4+ T cells display elevated expression of the HIV-1 co-receptor CCR5 and are more prone to HIV-1 latent infection. Here, we show that p53-regulated miRNA-103 downmodulates CCR5 levels in CD4+ T lymphocytes. We reveal that miRNA-103 mimics, as well as Nutl...

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Bibliographic Details
Main Authors: Nicolas Bellini, Robert Lodge, Tram N.Q. Pham, Jaspreet Jain, Thomas T. Murooka, Alon Herschhorn, Nicole F. Bernard, Jean-Pierre Routy, Cécile L. Tremblay, Éric A. Cohen
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:iScience
Subjects:
Biological sciences
molecular biology
immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222015061

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222015061

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