Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts
The skeleton is a unique structure capable of providing support for the body. Bone resorption and deposition are controlled in a tightly regulated balance between osteoblasts and osteoclasts with no net bone gain or loss. However, under conditions of disease, the balance between bone resorption and...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-06-01
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| Series: | Cancers |
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| Online Access: | http://www.mdpi.com/2072-6694/10/6/182 |
| _version_ | 1797758353584160768 |
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| author | Alison B. Shupp Alexus D. Kolb Dimpi Mukhopadhyay Karen M. Bussard |
| author_facet | Alison B. Shupp Alexus D. Kolb Dimpi Mukhopadhyay Karen M. Bussard |
| author_sort | Alison B. Shupp |
| collection | DOAJ |
| description | The skeleton is a unique structure capable of providing support for the body. Bone resorption and deposition are controlled in a tightly regulated balance between osteoblasts and osteoclasts with no net bone gain or loss. However, under conditions of disease, the balance between bone resorption and deposition is upset. Osteoblasts play an important role in bone homeostasis by depositing new bone osteoid into resorption pits. It is becoming increasingly evident that osteoblasts additionally play key roles in cancer cell dissemination to bone and subsequent metastasis. Our laboratory has evidence that when osteoblasts come into contact with disseminated breast cancer cells, the osteoblasts produce factors that initially reduce breast cancer cell proliferation, yet promote cancer cell survival in bone. Other laboratories have demonstrated that osteoblasts both directly and indirectly contribute to dormant cancer cell reactivation in bone. Moreover, we have demonstrated that osteoblasts undergo an inflammatory stress response in late stages of breast cancer, and produce inflammatory cytokines that are maintenance and survival factors for breast cancer cells and osteoclasts. Advances in understanding interactions between osteoblasts, osteoclasts, and bone metastatic cancer cells will aid in controlling and ultimately preventing cancer cell metastasis to bone. |
| first_indexed | 2024-03-12T18:28:48Z |
| format | Article |
| id | doaj.art-30d68342eba34c4e8b29958ef0edba32 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T18:28:48Z |
| publishDate | 2018-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-30d68342eba34c4e8b29958ef0edba322023-08-02T08:21:16ZengMDPI AGCancers2072-66942018-06-0110618210.3390/cancers10060182cancers10060182Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone OsteoblastsAlison B. Shupp0Alexus D. Kolb1Dimpi Mukhopadhyay2Karen M. Bussard3Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USADepartment of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USAThe skeleton is a unique structure capable of providing support for the body. Bone resorption and deposition are controlled in a tightly regulated balance between osteoblasts and osteoclasts with no net bone gain or loss. However, under conditions of disease, the balance between bone resorption and deposition is upset. Osteoblasts play an important role in bone homeostasis by depositing new bone osteoid into resorption pits. It is becoming increasingly evident that osteoblasts additionally play key roles in cancer cell dissemination to bone and subsequent metastasis. Our laboratory has evidence that when osteoblasts come into contact with disseminated breast cancer cells, the osteoblasts produce factors that initially reduce breast cancer cell proliferation, yet promote cancer cell survival in bone. Other laboratories have demonstrated that osteoblasts both directly and indirectly contribute to dormant cancer cell reactivation in bone. Moreover, we have demonstrated that osteoblasts undergo an inflammatory stress response in late stages of breast cancer, and produce inflammatory cytokines that are maintenance and survival factors for breast cancer cells and osteoclasts. Advances in understanding interactions between osteoblasts, osteoclasts, and bone metastatic cancer cells will aid in controlling and ultimately preventing cancer cell metastasis to bone.http://www.mdpi.com/2072-6694/10/6/182osteoblastosteoclastmetastasisbreast cancerprostate cancermultiple myelomabonedormancyre-activationosteomimicry |
| spellingShingle | Alison B. Shupp Alexus D. Kolb Dimpi Mukhopadhyay Karen M. Bussard Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts Cancers osteoblast osteoclast metastasis breast cancer prostate cancer multiple myeloma bone dormancy re-activation osteomimicry |
| title | Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts |
| title_full | Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts |
| title_fullStr | Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts |
| title_full_unstemmed | Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts |
| title_short | Cancer Metastases to Bone: Concepts, Mechanisms, and Interactions with Bone Osteoblasts |
| title_sort | cancer metastases to bone concepts mechanisms and interactions with bone osteoblasts |
| topic | osteoblast osteoclast metastasis breast cancer prostate cancer multiple myeloma bone dormancy re-activation osteomimicry |
| url | http://www.mdpi.com/2072-6694/10/6/182 |
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