Pinpointing the tumor-specific T cells via TCR clusters

Pinpointing the tumor-specific T cells via TCR clusters

Adoptive cell transfer (ACT) is a promising approach to cancer immunotherapy, but its efficiency fundamentally depends on the extent of tumor-specific T cell enrichment within the graft. This can be estimated via activation with identifiable neoantigens, tumor-associated antigens (TAAs), or living o...

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Bibliographic Details
Main Authors: Mikhail M Goncharov, Ekaterina A Bryushkova, Nikita I Sharaev, Valeria D Skatova, Anastasiya M Baryshnikova, George V Sharonov, Vadim Karnaukhov, Maria T Vakhitova, Igor V Samoylenko, Lev V Demidov, Sergey Lukyanov, Dmitriy M Chudakov, Ekaterina O Serebrovskaya
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
cancer immunotherapy
T cell receptor repertoires
PD-1+/CD39+
tumor-infiltrating lymphocytes
TCR clusters
tumor-associated antigens
Online Access:https://elifesciences.org/articles/77274

Internet

https://elifesciences.org/articles/77274

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