Multiple roles of ALK3 in osteoarthritis: a narrative review
Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage degradation, synovial membrane inflammation, osteophyte formation, and subchondral bone sclerosis. Pathological changes in cartilage and subchondral bone are the main processes in OA. In recent decades...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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The British Editorial Society of Bone & Joint Surgery
2023-07-01
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| Series: | Bone & Joint Research |
| Subjects: | |
| Online Access: | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.127.BJR-2022-0310.R1 |
| _version_ | 1797776158565072896 |
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| author | Xianchun Ruan Jinning Gu Mingyang Chen Fulin Zhao Munire Aili Demao Zhang |
| author_facet | Xianchun Ruan Jinning Gu Mingyang Chen Fulin Zhao Munire Aili Demao Zhang |
| author_sort | Xianchun Ruan |
| collection | DOAJ |
| description | Osteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage degradation, synovial membrane inflammation, osteophyte formation, and subchondral bone sclerosis. Pathological changes in cartilage and subchondral bone are the main processes in OA. In recent decades, many studies have demonstrated that activin-like kinase 3 (ALK3), a bone morphogenetic protein receptor, is essential for cartilage formation, osteogenesis, and postnatal skeletal development. Although the role of bone morphogenetic protein (BMP) signalling in articular cartilage and bone has been extensively studied, many new discoveries have been made in recent years around ALK3 targets in articular cartilage, subchondral bone, and the interaction between the two, broadening the original knowledge of the relationship between ALK3 and OA. In this review, we focus on the roles of ALK3 in OA, including cartilage and subchondral bone and related cells. It may be helpful to seek more efficient drugs or treatments for OA based on ALK3 signalling in future. |
| first_indexed | 2024-03-12T22:45:55Z |
| format | Article |
| id | doaj.art-30de049327294d7bbd3f5b1ba1a32304 |
| institution | Directory Open Access Journal |
| issn | 2046-3758 |
| language | English |
| last_indexed | 2024-03-12T22:45:55Z |
| publishDate | 2023-07-01 |
| publisher | The British Editorial Society of Bone & Joint Surgery |
| record_format | Article |
| series | Bone & Joint Research |
| spelling | doaj.art-30de049327294d7bbd3f5b1ba1a323042023-07-21T05:13:20ZengThe British Editorial Society of Bone & Joint SurgeryBone & Joint Research2046-37582023-07-0112739741110.1302/2046-3758.127.BJR-2022-0310.R1Multiple roles of ALK3 in osteoarthritis: a narrative reviewXianchun Ruan0Jinning Gu1Mingyang Chen2Fulin Zhao3Munire Aili4Demao Zhang5State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, ChinaOsteoarthritis (OA) is a chronic degenerative joint disease characterized by progressive cartilage degradation, synovial membrane inflammation, osteophyte formation, and subchondral bone sclerosis. Pathological changes in cartilage and subchondral bone are the main processes in OA. In recent decades, many studies have demonstrated that activin-like kinase 3 (ALK3), a bone morphogenetic protein receptor, is essential for cartilage formation, osteogenesis, and postnatal skeletal development. Although the role of bone morphogenetic protein (BMP) signalling in articular cartilage and bone has been extensively studied, many new discoveries have been made in recent years around ALK3 targets in articular cartilage, subchondral bone, and the interaction between the two, broadening the original knowledge of the relationship between ALK3 and OA. In this review, we focus on the roles of ALK3 in OA, including cartilage and subchondral bone and related cells. It may be helpful to seek more efficient drugs or treatments for OA based on ALK3 signalling in future.https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.127.BJR-2022-0310.R1alk3osteoarthritisjointosteoarthritis (oa)cartilage tissuesubchondral bonearticular cartilageossificationbone morphogenetic proteinsosteophyte formationcartilage formationinflammationsynovial membrane |
| spellingShingle | Xianchun Ruan Jinning Gu Mingyang Chen Fulin Zhao Munire Aili Demao Zhang Multiple roles of ALK3 in osteoarthritis: a narrative review Bone & Joint Research alk3 osteoarthritis joint osteoarthritis (oa) cartilage tissue subchondral bone articular cartilage ossification bone morphogenetic proteins osteophyte formation cartilage formation inflammation synovial membrane |
| title | Multiple roles of ALK3 in osteoarthritis: a narrative review |
| title_full | Multiple roles of ALK3 in osteoarthritis: a narrative review |
| title_fullStr | Multiple roles of ALK3 in osteoarthritis: a narrative review |
| title_full_unstemmed | Multiple roles of ALK3 in osteoarthritis: a narrative review |
| title_short | Multiple roles of ALK3 in osteoarthritis: a narrative review |
| title_sort | multiple roles of alk3 in osteoarthritis a narrative review |
| topic | alk3 osteoarthritis joint osteoarthritis (oa) cartilage tissue subchondral bone articular cartilage ossification bone morphogenetic proteins osteophyte formation cartilage formation inflammation synovial membrane |
| url | https://online.boneandjoint.org.uk/doi/epdf/10.1302/2046-3758.127.BJR-2022-0310.R1 |
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