Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

Saikosaponin D exerts antidepressant effect by regulating Homer1-mGluR5 and mTOR signaling in a rat model of chronic unpredictable mild stress

Abstract Background Many studies about depression have focused on the dysfunctional synaptic signaling in the hippocampus that drives the pathophysiology of depression. Radix Bupleuri has been used in China for over 2000 years to regulate liver-qi. Extracted from Radix Bupleuri, Saikosaponin D (SSD)...

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Bibliographic Details
Main Authors: Chen-Yue Liu, Jian-Bei Chen, Yue-Yun Liu, Xue-Ming Zhou, Man Zhang, You-Ming Jiang, Qing-Yu Ma, Zhe Xue, Zong-Yao Zhao, Xiao-Juan Li, Jia-Xu Chen
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Chinese Medicine
Subjects:
Saikosaponin D
Chronic unpredictable mild stress
Homer1-mGluR5
mTOR
Online Access:https://doi.org/10.1186/s13020-022-00621-8

Internet

https://doi.org/10.1186/s13020-022-00621-8

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