Apigenin, a Single Active Component of Herbal Extract, Alleviates Xerostomia via ERα-Mediated Upregulation of AQP5 Activation

Apigenin, a Single Active Component of Herbal Extract, Alleviates Xerostomia via ERα-Mediated Upregulation of AQP5 Activation

Xerostomia is a common symptom in menopausal women, suggesting the role of sex steroids in disease development. Shreds of literature had reported the potential use of herbal extracts to relieve xerostomia. However, a cocktail of multiple components in herbal extract makes it difficult to understand...

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Bibliographic Details
Main Authors: Wei Wei, Tingting Cao, Janak L. Pathak, Xintong Liu, Tianjiao Mao, Nobumoto Watanabe, Xiaomeng Li, Manli Zhang, Jiang Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
apigenin
xerostomia
aquaporin5 (AQP5)
estrogen receptor α (ERα)
ovariectomized (OVX) mice
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.818116/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.818116/full

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