Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton

Extracellular Vesicles Mediate Mesenchymal Stromal Cell-Dependent Regulation of B Cell PI3K-AKT Signaling Pathway and Actin Cytoskeleton

Mesenchymal stromal cells (MSCs) are adult, multipotent cells of mesodermal origin representing the progenitors of all stromal tissues. MSCs possess significant and broad immunomodulatory functions affecting both adaptive and innate immune responses once MSCs are primed by the inflammatory microenvi...

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Bibliographic Details
Main Authors: Annalisa Adamo, Jessica Brandi, Simone Caligola, Pietro Delfino, Riccardo Bazzoni, Roberta Carusone, Daniela Cecconi, Rosalba Giugno, Marcello Manfredi, Elisa Robotti, Emilio Marengo, Giulio Bassi, Paul Takam Kamga, Giada Dal Collo, Alessandro Gatti, Angela Mercuri, Maddalena Arigoni, Martina Olivero, Raffaele A. Calogero, Mauro Krampera
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
extracellular vesicles
mesenchymal stromal cells
B cells
high-throughput analysis
PI3K-AKT signaling pathway
actin cytoskeleton
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00446/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00446/full

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