Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma

Lentiviral mediated delivery of CRISPR/Cas9 reduces intraocular pressure in a mouse model of myocilin glaucoma

Abstract Mutations in myocilin (MYOC) are the leading known genetic cause of primary open-angle glaucoma, responsible for about 4% of all cases. Mutations in MYOC cause a gain-of-function phenotype in which mutant myocilin accumulates in the endoplasmic reticulum (ER) leading to ER stress and trabec...

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Bibliographic Details
Main Authors: Shruti V. Patil, Balasankara Reddy Kaipa, Sujata Ranshing, Yogapriya Sundaresan, J. Cameron Millar, Bhavani Nagarajan, Charles Kiehlbauch, Qihong Zhang, Ankur Jain, Charles C. Searby, Todd E. Scheetz, Abbot F. Clark, Val C. Sheffield, Gulab S. Zode
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Myocilin-associated Glaucoma
Gene therapy
Genome editing for glaucoma
Trabecular meshwork
Intraocular pressure
Viral vectors
Online Access:https://doi.org/10.1038/s41598-024-57286-6

Internet

https://doi.org/10.1038/s41598-024-57286-6

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