Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo

Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo

Background: s: Hyperhomocysteinemia (HHcy) is one of risk factors for vascular cognitive impairment (VCI). GTP cyclohydrolase 1 (GCH1) deficiency is critical to oxidative stress in vascular dysfunction. The aim of this study was designed to examine whether HHcy induces VCI through GCH1 S-nitrosylati...

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Bibliographic Details
Main Authors: Ya-Ling Yin, Yuan Chen, Feng Ren, Lu Wang, Mo-Li Zhu, Jun-Xiu Lu, Qian-Qian Wang, Cheng-Biao Lu, Chao Liu, Yong-Ping Bai, Shuang-Xi Wang, Jian-Zhi Wang, Peng Li
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Redox Biology
Subjects:
GTP cyclohydrolase 1
S-nitrosylation
Endothelial cell
Vascular cognitive impairment
Nitrosative stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231722003123

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http://www.sciencedirect.com/science/article/pii/S2213231722003123

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