Molecular mechanism of hyperactivation conferred by a truncation of TRPA1

Molecular mechanism of hyperactivation conferred by a truncation of TRPA1

Abstract A drastic TRPA1 mutant (R919*) identified in CRAMPT syndrome patients has not been mechanistically characterized. Here, we show that the R919* mutant confers hyperactivity when co-expressed with wild type (WT) TRPA1. Using functional and biochemical assays, we reveal that the R919* mutant c...

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Bibliographic Details
Main Authors: Avnika Bali, Samantha P. Schaefer, Isabelle Trier, Alice L. Zhang, Lilian Kabeche, Candice E. Paulsen
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38542-1

Internet

https://doi.org/10.1038/s41467-023-38542-1

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