Human Serine Racemase Weakly Binds the Third PDZ Domain of PSD-95

Human Serine Racemase Weakly Binds the Third PDZ Domain of PSD-95

Human serine racemase (hSR) is a pyridoxal-5′-phosphate (PLP)-dependent dimer that catalyzes the formation of D-serine from L-serine, as well as the dehydration of both L- and D-serine to pyruvate and ammonia. As D-serine is a co-agonist of N-methyl-D-aspartate receptors (NMDARs), hSR is a key enzym...

Full description

Bibliographic Details
Main Authors: Roberta Giaccari, Francesco Marchesani, Carlotta Compari, Emilia Fisicaro, Andrea Mozzarelli, Barbara Campanini, Stefano Bettati, Stefano Bruno, Serena Faggiano
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
serine racemase
D-serine
PDZ domain
PSD-95
SAP-90
DLG4
Online Access:https://www.mdpi.com/1422-0067/23/9/4959

Internet

https://www.mdpi.com/1422-0067/23/9/4959

Similar Items