Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells

Glutamine prevents acute kidney injury by modulating oxidative stress and apoptosis in tubular epithelial cells

Acute kidney injury (AKI) represents a common complication in critically ill patients that is associated with increased morbidity and mortality. In a murine AKI model induced by ischemia/reperfusion injury (IRI), we show that glutamine significantly decreases kidney damage and improves kidney functi...

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Bibliographic Details
Main Authors: Katharina Thomas, Lisa Zondler, Nadine Ludwig, Marina Kardell, Corinna Lüneburg, Katharina Henke, Sina Mersmann, Andreas Margraf, Tilmann Spieker, Tobias Tekath, Ana Velic, Richard Holtmeier, Juliane Hermann, Vera Jankowski, Melanie Meersch, Dietmar Vestweber, Martin Westphal, Johannes Roth, Michael A. Schäfers, John A. Kellum, Clifford A. Lowell, Jan Rossaint, Alexander Zarbock
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-11-01
Series:JCI Insight
Subjects:
Immunology
Nephrology
Online Access:https://doi.org/10.1172/jci.insight.163161

Internet

https://doi.org/10.1172/jci.insight.163161

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