Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation

Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation

Summary: Acetylation of histone H3 at lysine 27 is a well-defined marker of enhancer activity. However, the functional impact of this modification at enhancers is poorly understood. Here, we use a chemical genetics approach to acutely block the function of the cAMP response element binding protein (...

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Bibliographic Details
Main Authors: Ryan Raisner, Samir Kharbanda, Lingyan Jin, Edwin Jeng, Emily Chan, Mark Merchant, Peter M. Haverty, Russell Bainer, Tommy Cheung, David Arnott, E. Megan Flynn, F. Anthony Romero, Steven Magnuson, Karen E. Gascoigne
Format: Article
Language:English
Published: Elsevier 2018-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718311446

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http://www.sciencedirect.com/science/article/pii/S2211124718311446

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