Gold(I)-catalysed synthesis of a furan analogue of thiamine pyrophosphate

An analogue of thiamine having a furan ring in place of the thiazolium ring has been synthesised by a short and efficient route, involving gold(I)-catalysed cyclisation of an alkynyl alcohol to form the furan ring. The furan analogue of thiamine diphosphate (ThDP) was also made and tested for bindin...

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Bibliographic Details
Main Authors: Amjid Iqbal, El-Habib Sahraoui, Finian J. Leeper
Format: Article
Language:English
Published: Beilstein-Institut 2014-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.10.270