Targeted activation of midbrain neurons restores locomotor function in mouse models of parkinsonism

Here, the authors use cell-type specific stimulation of brainstem neurons within the caudal pedunculopontine nucleus to show that activation of excitatory neurons can normalize severe locomotor deficit in mouse models of parkinsonism. The study defines a potential target for neuromodulatory restorat...

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Bibliographic Details
Main Authors: Débora Masini, Ole Kiehn
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28075-4