Biotin attenuates heat shock factor 4b transcriptional activity by lysine 444 biotinylation

Biotin attenuates heat shock factor 4b transcriptional activity by lysine 444 biotinylation

Genetic mutations in HSF4 cause congenital cataracts. HSF4 exhibits both positive and negative regulation on the transcription of heat shock and non-heat shock proteins during lens development, and its activity is regulated by posttranslational modifications. Biotin is an essential vitamin that regu...

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Bibliographic Details
Main Authors: Longjun Yan, Jing Li, Jialin Hu, Junwei Qu, Kejia Li, Mingli Wang, Shuang-Shuang An, Cun-cun Ke, Hui Li, Fengling Yuan, Weikai Guo, Mengyue Hu, Jing Zhang, Zhengyan Yang, Hongmei Mu, Fengyan zhang, Jun Zhang, Xiukun Cui, Yanzhong Hu
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Hsf4
Biotin
Gene mutation
αB-crystallin
Gene transcription
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580822000280

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http://www.sciencedirect.com/science/article/pii/S2405580822000280

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