Human mitochondria require mtRF1 for translation termination at non-canonical stop codons

Human mitochondria require mtRF1 for translation termination at non-canonical stop codons

The mammalian mitochondrial genome contains two noncanonical stop codons, AGA and AGG. Here, the authors show that mtRF1, a mitochondrial protein of unknown function, triggers translation termination at AGA or AGG, placing mtRF1 among mitochondrial translation factors.

Bibliographic Details
Main Authors: Annika Krüger, Cristina Remes, Dmitrii Igorevich Shiriaev, Yong Liu, Henrik Spåhr, Rolf Wibom, Ilian Atanassov, Minh Duc Nguyen, Barry S. Cooperman, Joanna Rorbach
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35684-6

Internet

https://doi.org/10.1038/s41467-022-35684-6

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