Evolution of our understanding of myeloid regulatory cells: from MDSCs to Mregs
The term Myeloid-Derived Suppressor Cells (MDSCs) was first suggested in 2007 in order to reflect on the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggest that MDSCs suppress CTL and Th1 responses in malignant diseases...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00303/full |
| _version_ | 1828161997765607424 |
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| author | Masoud H Manjili Masoud H Manjili Xiang-Yang eWang Xiang-Yang eWang Scott eAbrams |
| author_facet | Masoud H Manjili Masoud H Manjili Xiang-Yang eWang Xiang-Yang eWang Scott eAbrams |
| author_sort | Masoud H Manjili |
| collection | DOAJ |
| description | The term Myeloid-Derived Suppressor Cells (MDSCs) was first suggested in 2007 in order to reflect on the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggest that MDSCs suppress CTL and Th1 responses in malignant diseases while they regulate effective immune responses in parasitic and helminth infections as well as Th17 inflammatory response during autoimmune diseases. Based on these data the term myeloid regulatory cells (Mregs) more accurately reflects their function and interactions with different cells of the immune system during diseased conditions. Here, we provide evidence on the multifaceted function of Mregs during diseased states. |
| first_indexed | 2024-04-12T00:47:55Z |
| format | Article |
| id | doaj.art-30fa303efdff4900ada02510b9505760 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-12T00:47:55Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-30fa303efdff4900ada02510b95057602022-12-22T03:54:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-07-01510.3389/fimmu.2014.0030399764Evolution of our understanding of myeloid regulatory cells: from MDSCs to MregsMasoud H Manjili0Masoud H Manjili1Xiang-Yang eWang2Xiang-Yang eWang3Scott eAbrams4Massey Cancer CenterVirginia Commonwealth UniversityVirginia Commonwealth UniversityMassey Cancer CenterRoswell Park Cancer InstituteThe term Myeloid-Derived Suppressor Cells (MDSCs) was first suggested in 2007 in order to reflect on the origin and function of myeloid cells during immunosuppression in cancer and other pathologic conditions. Emerging evidence suggest that MDSCs suppress CTL and Th1 responses in malignant diseases while they regulate effective immune responses in parasitic and helminth infections as well as Th17 inflammatory response during autoimmune diseases. Based on these data the term myeloid regulatory cells (Mregs) more accurately reflects their function and interactions with different cells of the immune system during diseased conditions. Here, we provide evidence on the multifaceted function of Mregs during diseased states.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00303/fullHelminthsLeishmaniaNippostrongylusmyeloid-derived suppressor cellsimmunotherapy of cancermyeloid regulatory cells |
| spellingShingle | Masoud H Manjili Masoud H Manjili Xiang-Yang eWang Xiang-Yang eWang Scott eAbrams Evolution of our understanding of myeloid regulatory cells: from MDSCs to Mregs Frontiers in Immunology Helminths Leishmania Nippostrongylus myeloid-derived suppressor cells immunotherapy of cancer myeloid regulatory cells |
| title | Evolution of our understanding of myeloid regulatory cells: from MDSCs to Mregs |
| title_full | Evolution of our understanding of myeloid regulatory cells: from MDSCs to Mregs |
| title_fullStr | Evolution of our understanding of myeloid regulatory cells: from MDSCs to Mregs |
| title_full_unstemmed | Evolution of our understanding of myeloid regulatory cells: from MDSCs to Mregs |
| title_short | Evolution of our understanding of myeloid regulatory cells: from MDSCs to Mregs |
| title_sort | evolution of our understanding of myeloid regulatory cells from mdscs to mregs |
| topic | Helminths Leishmania Nippostrongylus myeloid-derived suppressor cells immunotherapy of cancer myeloid regulatory cells |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00303/full |
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