Design, Synthesis, and Biological Evaluation of Novel Tomentosin Derivatives in NMDA-Induced Excitotoxicity

Design, Synthesis, and Biological Evaluation of Novel Tomentosin Derivatives in NMDA-Induced Excitotoxicity

N-methyl-D-aspartate (NMDA) receptor stimulation may lead to excitotoxicity, which triggers neuronal death in brain disorders. In addition to current clinical therapeutic approaches, treatment strategies by phytochemicals or their derivatives are under investigation for neurodegenerative diseases. I...

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Bibliographic Details
Main Authors: Mohamed Zaki, Mohammed Loubidi, Tuğçe Bilgiç, Derviş Birim, Mohamed Akssira, Taner Dagcı, Sabine Berteina-Raboin, Luciano Saso, Mostafa Khouili, Güliz Armagan
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Pharmaceuticals
Subjects:
oxidative stress
excitotoxicity
apoptosis
amino-tomentosin
1,2,3-triazolo-tomentosin
Online Access:https://www.mdpi.com/1424-8247/15/4/421

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https://www.mdpi.com/1424-8247/15/4/421

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