Chronic in utero mitral inflow obstruction unloads left ventricular volume in a novel late gestation fetal lamb modelCentral MessagePerspective

Objective: The in utero no flow/no grow hypothesis postulates that reduced inflow of blood into the left ventricle due to a stenotic mitral valve could lead to ventricular hypoplasia and hypoplastic left heart syndrome. This has been demonstrated in chick embryos, but less so in large animals. We in...

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Bibliographic Details
Main Authors: Daisuke Onohara, MD, PhD, Matthew Hagen, PhD, Samantha Louey, PhD, George Giraud, MD, PhD, Sonnet Jonker, PhD, Muralidhar Padala, PhD
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:JTCVS Open
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666273623003091