Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

Abstract Background Cisplatin-based chemotherapy is frequently used to treat advanced gastric cancer (GC). However, the resistance often occurs with the mechanisms being not well understood. Recently, emerging evidence indicates that tumor-associated macrophages (TAMs) play an important role in chem...

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Bibliographic Details
Main Authors: Peiming Zheng, Lei Chen, Xiangliang Yuan, Qin Luo, Yi Liu, Guohua Xie, Yanhui Ma, Lisong Shen
Format: Article
Language:English
Published: BMC 2017-04-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cisplatin resistance
Tumor-associated macrophages
Exosome
miR-21
Gastric cancer
Online Access:http://link.springer.com/article/10.1186/s13046-017-0528-y

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http://link.springer.com/article/10.1186/s13046-017-0528-y

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