The Histone Deacetylase Inhibitors MS-275 and SAHA Suppress the p38 Mitogen-Activated Protein Kinase Signaling Pathway and Chemotaxis in Rheumatoid Arthritic Synovial Fibroblastic E11 Cells

The Histone Deacetylase Inhibitors MS-275 and SAHA Suppress the p38 Mitogen-Activated Protein Kinase Signaling Pathway and Chemotaxis in Rheumatoid Arthritic Synovial Fibroblastic E11 Cells

MS-275 (entinostat) and SAHA (vorinostat), two histone deacetylase (HDAC) inhibitors currently in oncological trials, have displayed potent anti-rheumatic activities in rodent models of rheumatoid arthritis (RA). To further elucidate their anti-inflammatory mechanisms, the impact of MS-275 and SAHA...

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Bibliographic Details
Main Authors: Hai-Shu Lin, Yoshiya Tanaka, Paul C Ho, Qiu-Yi Choo
Format: Article
Language:English
Published: MDPI AG 2013-11-01
Series:Molecules
Subjects:
histone deacetylase inhibitor
rheumatoid arthritis
MS-275
SAHA
p38 MAPK
MKP-1
chemotaxis
Online Access:http://www.mdpi.com/1420-3049/18/11/14085

Internet

http://www.mdpi.com/1420-3049/18/11/14085

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