Age-Related Decline in Nrf2/ARE Signaling Is Associated with the Mitochondrial DNA Damage and Cognitive Impairments

Age-Related Decline in Nrf2/ARE Signaling Is Associated with the Mitochondrial DNA Damage and Cognitive Impairments

In this research, we compared the cognitive parameters of 2-, 7-, and 15-month-old mice, changes in mitochondrial DNA (mtDNA) integrity and expression of genes involved in the nuclear erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE) signaling pathway. We showed an age-related dec...

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Bibliographic Details
Main Authors: Artem P. Gureev, Victoria G. Khorolskaya, Irina S. Sadovnikova, Ekaterina A. Shaforostova, Vadim R. Cherednichenko, Inna Y. Burakova, Egor Y. Plotnikov, Vasily N. Popov
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
aging
cognitive deficit
nuclear erythroid 2-related factor 2
mammalian target of rapamycin complex 1
brain-derived neurotrophic factor
mitochondrial DNA damage
Online Access:https://www.mdpi.com/1422-0067/23/23/15197

Internet

https://www.mdpi.com/1422-0067/23/23/15197

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