An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

An atlas of the binding specificities of transcription factors in Pseudomonas aeruginosa directs prediction of novel regulators in virulence

A high-throughput systematic evolution of ligands by exponential enrichment assay was applied to 371 putative TFs in Pseudomonas aeruginosa, which resulted in the robust enrichment of 199 unique sequence motifs describing the binding specificities of 182 TFs. By scanning the genome, we predicted in...

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Bibliographic Details
Main Authors: Tingting Wang, Wenju Sun, Ligang Fan, Canfeng Hua, Nan Wu, Shaorong Fan, Jilin Zhang, Xin Deng, Jian Yan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
Pseudomonas aeruginosa
transcription factors
dna binding specificity
transcriptional regulation network
virulence
gene expression
Online Access:https://elifesciences.org/articles/61885

Internet

https://elifesciences.org/articles/61885

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