Adenosine kinase inhibition protects against cranial radiation-induced cognitive dysfunction

Adenosine kinase inhibition protects against cranial radiation-induced cognitive dysfunction

Clinical radiation therapy for the treatment of CNS cancers leads to unintended and debilitating impairments in cognition. Radiation-induced cognitive dysfunction is long lasting, however, the underlying molecular and cellular mechanisms are still not well established. Since ionizing radiation cause...

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Bibliographic Details
Main Authors: Munjal M Acharya, Janet E Baulch, Theresa A Lusardi, Barrett D Allen, Nicole N Chmielewski, Al Anoud Doud Baddour, Charles L Limoli, Detlev eBoison
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Adenosine
Adenosine Kinase
Cranial Irradiation
Fear conditioning
Neuroprotection
cancer therapy
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00042/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2016.00042/full

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