Non-Catalytic Participation of the Pin1 Peptidyl-Prolyl Isomerase Domain in Target Binding

Pin1 is a phosphorylation-dependent peptidyl-prolyl isomerase that has the potential to add an additional level of regulation within protein kinase mediated signaling pathways. Furthermore, there is a mounting body of evidence implicating Pin1 in the emergence of pathological phenotypes in neurodeg...

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Bibliographic Details
Main Authors: Brendan Tooke Innes, Melanie L. Bailey, Christopher J Brandl, Brian H. Shilton, David William Litchfield
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-02-01
Series:Frontiers in Physiology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00018/full