Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production.

Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production.

<h4>Background</h4>Sphingosine-1-phosphate receptor 3 (S1P3) is one of five receptors for sphingosine-1-phosphate (S1P). S1P/S1P3 signaling is involved in numerous physiological and pathological processes including bone metabolism, sepsis, cancer, and immunity. In rheumatoid arthritis (R...

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Main Authors: Takuya Inoue, Masataka Kohno, Hidetake Nagahara, Ken Murakami, Tomoya Sagawa, Akiko Kasahara, Shunya Kaneshita, Takashi Kida, Kazuki Fujioka, Makoto Wada, Hiroshi Nakada, Timothy Hla, Yutaka Kawahito
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0218090

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https://doi.org/10.1371/journal.pone.0218090

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