Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT

Erythropoietin receptor regulates tumor mitochondrial biogenesis through iNOS and pAKT

Erythropoietin receptor (EPOR) is widely expressed in healthy and malignant tissues. In certain malignancies, EPOR stimulates tumor growth. In healthy tissues, EPOR controls processes other than erythropoiesis, including mitochondrial metabolism. We hypothesized that EPOR also controls the mitochond...

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Bibliographic Details
Main Authors: Mostafa A. Aboouf, Franco Guscetti, Nadine von Büren, Julia Armbruster, Hyrije Ademi, Maja Ruetten, Florinda Meléndez-Rodríguez, Thomas Rülicke, Alexander Seymer, Robert A. Jacobs, Edith M. Schneider Gasser, Julian Aragones, Drorit Neumann, Max Gassmann, Markus Thiersch
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
erythropoietin receptor
tumor metabolism
mitochondrial biogenesis
nitric oxide (NO)
respirometry
OXPHOS
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.976961/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.976961/full

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