Apolipoprotein E4 Effects a Distinct Transcriptomic Profile and Dendritic Arbor Characteristics in Hippocampal Neurons Cultured in vitro

Apolipoprotein E4 Effects a Distinct Transcriptomic Profile and Dendritic Arbor Characteristics in Hippocampal Neurons Cultured in vitro

The APOE gene is diversified by three alleles ε2, ε3, and ε4 encoding corresponding apolipoprotein (apo) E isoforms. Possession of the ε4 allele is signified by increased risks of age-related cognitive decline, Alzheimer’s disease (AD), and the rate of AD dementia progression. ApoE is secreted by as...

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Bibliographic Details
Main Authors: Jenny R. Diaz, Mitchell Martá-Ariza, Alireza Khodadadi-Jamayran, Adriana Heguy, Aristotelis Tsirigos, Joanna E. Pankiewicz, Patrick M. Sullivan, Martin J. Sadowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
ApoE
gene ontology analysis
KEGG enrichment analysis
neurodegeneration
primary hippocampal cell cultures
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2022.845291/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2022.845291/full

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