High Glucose Exposure Impairs L-Cell Differentiation in Intestinal Organoids: Molecular Mechanisms and Clinical Implications

High Glucose Exposure Impairs L-Cell Differentiation in Intestinal Organoids: Molecular Mechanisms and Clinical Implications

Intestinal organoids are used to analyze the differentiation of enteroendocrine cells (EECs) and to manipulate their density for treating type 2 diabetes. EEC differentiation is a continuous process tightly regulated in the gut by a complex regulatory network. However, the effect of chronic hypergly...

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Bibliographic Details
Main Authors: Agnese Filippello, Stefania Di Mauro, Alessandra Scamporrino, Roberta Malaguarnera, Sebastiano Alfio Torrisi, Gian Marco Leggio, Antonino Di Pino, Roberto Scicali, Francesco Purrello, Salvatore Piro
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
intestinal hormones
differentiation
enteroendocrine cells
glucotoxicity
intestinal organoids
Online Access:https://www.mdpi.com/1422-0067/22/13/6660

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https://www.mdpi.com/1422-0067/22/13/6660

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